DSIP (Delta Sleep-Inducing Peptide) 5mg Nasal Spray
DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide that regulates sleep, reduces stress, and supports natural melatonin production.
It has been studied for its ability to improve deep sleep, reset circadian rhythms, and lower cortisol.
Nasal spray delivery of DSIP is gaining popularity due to its potential for direct brain absorption,
bypassing the digestive system and possibly enhancing bioavailability compared to injections.
Description
DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide that regulates sleep, reduces stress, and supports natural melatonin production.
It has been studied for its ability to improve deep sleep, reset circadian rhythms, and lower cortisol.
Nasal spray delivery of DSIP is gaining popularity due to its potential for direct brain absorption,
bypassing the digestive system and possibly enhancing bioavailability compared to injections.
1. How DSIP Nasal Spray Works
- Mechanism of Action:
- Stimulates delta-wave sleep (deep, restorative sleep)
- Modulates cortisol (reduces stress-related insomnia)
- Enhances melatonin secretion (without supplementation)
- May have neuroprotective & anti-addictive effects (anecdotal reports)
- Nasal Absorption Benefits:
- Potential faster brain uptake via olfactory/trigeminal pathways
- Avoids first-pass liver metabolism (unlike oral peptides)
2. DSIP Nasal Spray Research Dosage & Protocol
Since DSIP is not FDA-approved, dosing is based on research studies, and peptide clinic protocols.
Common Dosage Ranges:
| Form | Dosage | Frequency | Cycle Length |
|---|---|---|---|
| Nasal Spray | 50–200 mcg (0.05–0.2 mg) | 1x nightly (before bed) | 10–30 days |
| Subcutaneous Injection | 100–300 mcg/day | 1x nightly | 10–20 days |
| IV/IM (Rare) | Up to 500 mcg | Clinics only | Short-term |
Typical Nasal Spray Protocol:
- 100 mcg per spray (1 spray per nostril = 200 mcg total)
- Taken 30–60 mins before bedtime
- Used for 10–30 days, then take a break (to avoid tolerance)
3. Effectiveness: Nasal vs. Injection
| Factor | Nasal Spray | Injection |
|---|---|---|
| Bioavailability | ~30–50% (estimated) | ~70–90% |
| Onset of Effects | Faster (15–30 mins) | Slower (30–60 mins) |
| Convenience | No needles | More precise dosing |
| Reported Effects | Mild to moderate | Stronger (studies) |
Conclusion:
- Nasal spray is better for convenience and quick effects.
- Injection may be more reliable for severe insomnia.
4. Benefits of DSIP
- Deeper, more restorative sleep (increases delta waves)
- Reduces nighttime cortisol (helps stress-related insomnia)
- Non-habit forming (unlike prescription sleep aids)
- May improve mood & recovery (anecdotal reports)

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