Description

DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide that regulates sleep, reduces stress, and supports natural melatonin production.

It has been studied for its ability to improve deep sleep, reset circadian rhythms, and lower cortisol.

Nasal spray delivery of DSIP is gaining popularity due to its potential for direct brain absorption,

bypassing the digestive system and possibly enhancing bioavailability compared to injections.

1. How DSIP Nasal Spray Works

  • Mechanism of Action:
    • Stimulates delta-wave sleep (deep, restorative sleep)
    • Modulates cortisol (reduces stress-related insomnia)
    • Enhances melatonin secretion (without supplementation)
    • May have neuroprotective & anti-addictive effects (anecdotal reports)
  • Nasal Absorption Benefits:
    • Potential faster brain uptake via olfactory/trigeminal pathways
    • Avoids first-pass liver metabolism (unlike oral peptides)

2. DSIP Nasal Spray Research Dosage & Protocol

Since DSIP is not FDA-approved, dosing is based on research studies, and peptide clinic protocols.

Common Dosage Ranges:

Form Dosage Frequency Cycle Length
Nasal Spray 50–200 mcg (0.05–0.2 mg) 1x nightly (before bed) 10–30 days
Subcutaneous Injection 100–300 mcg/day 1x nightly 10–20 days
IV/IM (Rare) Up to 500 mcg Clinics only Short-term

Typical Nasal Spray Protocol:

  • 100 mcg per spray (1 spray per nostril = 200 mcg total)
  • Taken 30–60 mins before bedtime
  • Used for 10–30 days, then take a break (to avoid tolerance)

3. Effectiveness: Nasal vs. Injection

Factor Nasal Spray Injection
Bioavailability ~30–50% (estimated) ~70–90%
Onset of Effects Faster (15–30 mins) Slower (30–60 mins)
Convenience No needles More precise dosing
Reported Effects Mild to moderate Stronger (studies)

Conclusion:

  • Nasal spray is better for convenience and quick effects.
  • Injection may be more reliable for severe insomnia.

4. Benefits of DSIP

  • Deeper, more restorative sleep (increases delta waves)
  • Reduces nighttime cortisol (helps stress-related insomnia)
  • Non-habit forming (unlike prescription sleep aids)
  • May improve mood & recovery (anecdotal reports)

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